Organoid research is revolutionizing our understanding of human biology by providing three-dimensional, physiologically relevant models of human tissues. Key techniques include patch clamp electrophysiology, microelectrode arrays (MEAs), and optical manipulation, each of which unique advantages for studying the functional properties of organoids.
A recent Eli Lilly study highlights Jacketed External Telemetry (JET) as the superior method for nonclinical QTc assessment, outperforming multilead snapshot recordings in both statistical and pharmacological sensitivity. JET’s ability to capture high-fidelity ECG data from conscious, freely moving animals makes it more clinically relevant and regulatory-aligned. Backed by 2022 ICH E14/S7B updates, JET sets a new standard for cardiac safety in toxicology studies.
In a move that could reshape the landscape of preclinical drug development, the Food and Drug Administration (FDA) recently announced a plan to phase out its requirement for use of animal models in evaluating monoclonal antibodies (mAbs) and other drug candidates.
DSI's SoHo Implantable Telemetry platform revolutionizes small animal research by enabling comprehensive biopotential monitoring. Capture EEG, EMG, ECG, body temperature, and locomotor activity with minimal invasiveness. Designed for extra-small to medium animal models, this system enhances research precision, reduces experimental stress, and provides unprecedented insights across neuroscience, cardiovascular, and behavioral studies.
Organoid electrophysiology is providing pharmaceutical and biotech companies with human-relevant models for testing drug efficacy, modeling diseases, and reducing reliance on animal studies, ultimately accelerating the development of safer and more effective therapeutics.
The integration of behavioral telemetry and organoid research is transforming neuroscience and biomedical science by linking cellular models with complex biological behaviors.
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Unlike traditional MEA recordings that can only measure field potentials, the IntraCell uses a laser to precisely optoporate cardiomyocytes underneath each electrode.
Microelectrode arrays – also known as “multielectrode arrays” or MEAs – are powerful tools used in neuroscience, cardiac research, and pharmacology to study the electrical activity of excitable tissues like neurons and cardiac cells. But what exactly is an MEA system, and how do they work?
